ABSTRACT
The article considers the features of the use of simulation technologies in distance learning, including in a complex epidemiological situation. The Purpose of the Work: To evaluate the role of simulation technologies in distance learning of senior students of medical universities. The study included 29 6th-year students of the medical institute of the Chechen state university (Grozny, Russia). The introduction of simulation technologies makes it possible to improve the connection of theoretical material with clinical practice, increase interest in learning and self-discipline.
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This article presents a proposed insight into the anti-viral potential of silver nanoparticles against novel coronavirus disease (COVID-19). Possible mechanisms of influence of silver nanoparticles on the coronavirus are considered. Models of nanosilver complexes with spike protein of coronavirus amino acids were constructed using computer quantum-chemical modeling. The values of electron density distribution, highest occupied molecular orbital, lowest unoccupied molecular orbital and electron density distribution gradient for each constructed model are obtained. Analysis of the obtained data showed that the most energy-efficient interaction is the formation of the "tryptophan-nanosilver" complex (E=-5856.83 kkal/mol). According to the results of quantum chemical calculations, the most stable complex is the "cysteine-Ag nanoparticles" complex (Delta E = 0.16 a.u.).
ABSTRACT
The developed HoloDoctor software package allows performing surgical operations in real time. It should be emphasized that the operation time on the HoloDoctor PC is reduced by 20-30% compared to traditional methods. The performance of HoloLens glasses with our program is high, while allowing the doctor to save time. The complex provides diagnostics, therapy planning, treatment adjustment as needed and minimizes the risk of medical error. HoloDoctor can be used in educational practice by integrating it into educational programs for medical specialties.
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In this paper, the contrasting properties of titanium dioxide nanoparticles in various compositions were considered. In the course of the work, methods for the synthesis of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2 and SiO2-TiO2-ZrO2 were developed;the microstructure of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO(2)and SiO2-TiO2-ZrO(2)was studied;the stability of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO(2)and SiO2-TiO2-ZrO2 was determined. The elemental composition of the oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO(2)and SiO2-TiO2-ZrO2 has also been studied using SEM and XRD methods. It was found that SiO2-TiO2-ZrO2 nanocomposites with content of titanium dioxide from 8 to 9.5 % and zirconium dioxide from 0.5 to 2 % are completely insoluble in a highly alkaline medium. Thus, this composition is the most optimal for use as a contrast agent in optical coherence tomography.
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The aim of the study was to determine the effect of the inhibitor of janus kinase - baricitinib ("Olumiant") on the course of COVID-19. This drug baricitinib is able to suppress the systemic inflammatory response, which is one of the common causes of death in COVID-19, is an urgent problem of the study. The study was carried out in the Regional Specialized Budget Infectious Diseases Hospital of Stavropol (Russian Federation, Stavropol Region). In a multivariate analysis, it was shown that the use of baricitinib was associated with a decrease in the frequency of the primary endpoint of death/need for invasive lung ventilation. The use of baricitinib was quite safe, but in some patients there was an increase in the level of transaminases. No cases of hypercoagulation have been reported while taking baricitinib. It was found that patients with a normal BMI are more sensitive to therapy than those who are overweight.75% of patients in the first group had a temperature above 38.0 degrees C. However, against the background of taking the standard treatment regimen and baricitinib, it was noted that the temperature stabilized during the day and did not rise again. Against the background of taking baricitinib, the elimination of the phenomena of respiratory failure and the refusal of an oxygen mask occurred 3.1 times more often than without baricitinib. The authors concluded that the use of baricitinib can be considered as an additional therapy for moderate forms of pneumonia in patients over 65 years or in patients with concomitant chronic diseases in order to suppress the reactions of systemic inflammation and the development of serious respiratory and other system lesions caused by COVID-19.
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The purpose of this scientific article is to show the possibility of using the HoloDoctor software and hardware complex, which includes the following modules: the anatomical atlas module, the data analysis module and the surgical intervention simulation module. HoloDoctor allows us to perform surgical operations in real time. The time of operations using the HoloDoctor is reduced by 20-30% compared to traditional methods. The developed complex provides diagnostics of treatment planning, correction of the treatment plan, minimizing the risk of medical error. The developed product can be used in educational practice by introducing it into educational programs of medical specialties.
ABSTRACT
This article presents an analysis of available scientific data on the morphology and nanostructure of the COVID-19 coronavirus. Possible mechanisms of influence of nanosilver particles on the coronavirus are considered. Models of nanosilver complexes with spike protein of coronavirus amino acids were constructed using computer quantum-chemical modeling. The values of electron density distribution, highest occupied molecular orbital, lowest unoccupied molecular orbital, and electron density distribution gradient for each constructed model are obtained. As a result of quantum chemical modeling, it was found that silver nanoparticles can interact with the following amino acids: Proline, glutamine, lysine, arginine, asparagine, histidine, glutamic and aspartic acids, tryptophan, and cysteine, which is due to the presence of additional -NH2, -NH, -SH and -COOH groups in these amino acids that are not involved in the formation of a peptide bond. The freedom of additional groups makes it possible to interact with nanosilver. Analysis of the obtained data showed that the most energy-efficient interaction is the formation of the "tryptophan-nanosilver" complex (E= - 5856.83 kcal/mol). Based on the findings of quantum chemical calculations, the most stable complex is the "cysteine- nanosilver" (Delta E = 0.16 a.u). Copyright (C) 2013 - All Rights Reserved - Pharmacophore
ABSTRACT
The SARS-CoV-2 turned out to be aggressive, and the number of diseases around the world continues to grow to the present. According to observational studies, people with chronic diseases are more a trisk for severe COVID-19 disease. Endocrinologists are faced with new tasks-to inform persons with endocrinopathies as quickly as possible about the risks that their health could potentially cause, a pandemic;on infection prevention methods and management tactics for people with endocrinopathies in the face of a virus-caused disease.
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The study of the etiology of acute respiratory infections in 4022 hospitalized children aged 1 month to 14 years revealed the involvement of coronavirus in 12.4% of cases (500 children) more often in combination with other pathogens. In the case of coronavirus infection, moderate forms of the infectious process prevail mainly in the form of rhino-pharyngo-tracheitis against the background of subfebrile and febrile temperatures with moderate symptoms of intoxication. Majority of the children had dyspeptic symptoms. Every third child may have a lower respiratory tract lesion (bronchitis, pneumonia). Copyright (c) 2013 - All Rights Reserved - Pharmacophore